Was ist eine Prothrombin-Mutation?
Die Prothrombin-Mutation 20210G>A ist ein angeborener Gendefekt, bei dem es zu erhöhten Blutspiegeln von Gerinnungsfaktor II („Prothrombin“) kommt. Die Folge ist ein erhöhtes Risiko für das Auftreten von Venenthrombosen („Thrombophilie“).
Was ist Prothrombin-Mutation Faktor-V-Leiden?
Faktor-V-Leiden-Mutation (F5LMT) Die Faktor-V-Leiden-Mutation ist ein häufiger, angeborener Gendefekt, bei dem es zu Störungen der Blutgerinnung kommt. Dabei besteht insbesondere ein erhöhtes Risiko für das Auftreten von Venenthrombosen.
What is a prothrombin time test?
A prothrombin time (PT) test measures how long it takes for a clot to form in a blood sample. An INR (international normalized ratio) is a type of calculation based on PT test results. Prothrombin is a protein made by the liver. It is one of several substances known as clotting (coagulation) factors.
What does a high protrombin time mean?
The „prothrombin time“ (PT) is one way of measuring how long it takes blood to form a clot, and it is measured in seconds (such as 13.2 seconds). A normal PT indicates that a normal amount of blood-clotting protein is available. Explanation of test results: When the PT is high, it takes longer for the blood to clot (17 seconds, for example).
What can cause prolonged prothrombin time to be prolonged?
Interpretation. The prothrombin time can be prolonged as a result of deficiencies in vitamin K, warfarin therapy, malabsorption, or lack of intestinal colonization by bacteria (such as in newborns ). In addition, poor factor VII synthesis (due to liver disease) or increased consumption (in disseminated intravascular coagulation) may prolong the PT.
What does a high pT mean in a blood test?
A high PT usually means that there is serious liver damage or cirrhosis. A high PT may indicate there is a higher risk for internal bleeding from the upper part of the GI tract (esophagus, stomach). Other things to know: Some patients take a drug called Coumadin (warfarin), which elevates the PT for the purpose of „thinning“ the blood.