Inhaltsverzeichnis
Was ist ein KPC Virus?
Klebsiella-pneumoniae-Carbapenemasen, kurz KPC, sind bakterielle Enzyme aus der Gruppe der Serinproteasen, die zu einer Antibiotikaresistenz führen.
Was machen klebsiellen?
Eine Spezies der Klebsiella produziert ein Toxin, das nach der Einnahme von Antibiotika eine Entzündung des Dickdarms mit Blutungen (hämorrhagische Kolitis) hervorrufen kann. Diese Erkrankung wird als antibiotikaassoziierte Kolitis bezeichnet. Die Antibiotika töten Bakterien ab, die normalerweise im Darm vorkommen.
What is the role of KPCS in the pathogenesis of K pneumoniae?
KPCs are an important mechanism of resistance for an increasingly wide range of Gram-negative bacteria and are no longer limited to K pneumoniae. KPC-producing bacteria are often misidentified by routine microbiological susceptibility testing and incorrectly reported as sensitive to carbapenems; however,…
What is the history of KPC in the United States?
Following the initial sporadic outbreaks in New York City, bacteria-producing KPC enzymes became endemic in many hospitals in the New York and New Jersey area. In the ensuing decade, KPC-producing bacteria have spread throughout the US and worldwide.
What is the role of carbapenem resistance in the diagnosis of KPC?
KPC-producing bacteria are often misidentified by routine microbiological susceptibility testing and incorrectly reported as sensitive to carbapenems; however, resistance to the carbapenem antibiotic ertapenem is common and a better indicator of the presence of KPCs.
Does Klebsiella pneumoniae bla(KPC-2) gene influence beta-lactam susceptibility?
Three isoforms of Klebsiella pneumoniae bla(KPC-2) gene were used to transform Escherichia coli W4573 and its deletion mutant of an efflux pump (AcrAB) to examine the effects on beta-lactam susceptibility. Data indicate that the bla carbapenemase (KPC) KPC-2 gene itself was not associated to increased virulence.