Inhaltsverzeichnis
Was ist eine Intrathekale IgG Synthese?
Eine intrathekale IgG-Synthese ist der Leitbefund bei fast allen humoralen Immmunreaktionen des ZNS. Sie ist ein Indikator subakuter und chronischer ZNS- Entzündungen.
Was kann man im Liquor untersuchen?
Die Untersuchung des Liquor („Nervenwassers“) ist für die Diagnose einer großen Zahl von neurologischen Erkrankungen erforderlich. Neben der Routineuntersuchung von Zellzahl, Eiweiß, Glukose, Lactat sind zahlreiche Spezialuntersuchungen möglich.
Was kann man bei einer Lumbalpunktion feststellen?
Lumbalpunktion als diagnostisches Mittel Die Liquorpunktion dient dem Nachweis beziehungsweise dem Ausschluss verschiedener Erkrankungen: Hirn- und Rückenmarkstumore. Krebsbefall der Hirnhäute, zum Beispiel bei Lymphomen. entzündliche Erkrankungen des Gehirns (Enzephalitis) oder der Hirnhäute (Meningitis)
What do oligoclonal bands in CSF indicate?
The significance of serum oligoclonal bands in neurological diseases The presence of oligoclonal bands (OCBs) of immunoglobulin G (IgG) in CSF provides evidence for the occurrence of a humoral immune response, but it is not always appreciated that the oligoclonal IgG may have originated in the serum.
Do oligoclonal bands of immunoglobulin G (IgG) originate in serum?
The presence of oligoclonal bands (OCBs) of immunoglobulin G (IgG) in CSF provides evidence for the occurrence of a humoral immune response, but it is not always appreciated that the oligoclonal IgG may have originated in the serum.
What does a positive oligoclonal band assay mean?
When the oligoclonal band assay detects 2 or more unique IgG bands in the cerebrospinal fluid (CSF), the result is positive. CSF is used in the diagnosis of multiple sclerosis (MS) by identifying increased intrathecal IgG synthesis qualitatively (oligoclonal bands).
Is CSF-specific IgG synthesis specific in multiple sclerosis?
These findings, however, are not specific for MS as CSF-specific IgG synthesis may also be found in patients with other neurologic diseases including infectious, inflammatory, cerebrovascular, and paraneoplastic disorders. Clinical correlation recommended. 1.
What is an oligoclonal band Test?
The word oligoclonal band comes from the fact that the immunoglobulins appear as separate bands when the CSF is put in a gel plate under the effect of an electric current. Along with the CSF test, the serum (the liquid component of blood without clotting proteins) is also tested for oligoclonal bands.
What do oligoclonal IgG bands in multiple sclerosis cerebrospinal fluid mean?
Oligoclonal bands in multiple sclerosis cerebrospinal fluid: an update on methodology and clinical usefulness Two or more oligoclonal IgG bands (OB) detected by separation of cerebrospinal fluid (CSF) proteins while not demonstrable in corresponding serum reflect a local B-cell response accompanying central nervous system (CNS) inflammation.