Welche Rolle spielt das Medikament EPO bei der Behandlung von Anämie?
EPO hemmt den programmierten Zelltod (Apoptose) der Erythrozyten-Vorläufer im Knochenmark und fördert deren Proliferation (5). Das Hormon bindet an spezifische Rezeptoren (EPO-R). Dies sind transmembranäre Glykoproteine von etwa 60 kDa (484 Aminosäuren).
Was ist Elapor?
Elapor® Markenname der Firma Multiplex. Aus kleinen Kugeln expandierter Hartschaum, der zäher als Styropor ist, also Beanspruchung auf Zug bis zum Bruch deutlich besser aushält. Elapor ist resistent gegen die meisten Kleber und Lacke.
How does testosterone stimulate erythropoiesis?
Testosterone-induced increase in hemoglobin and hematocrit is associated with stimulation of EPO and reduced ferritin and hepcidin concentrations. We propose that testosterone stimulates erythropoiesis by stimulating EPO and recalibrating the set point of EPO in relation to hemoglobin and by increasing iron utilization for erythropoiesis.
Is short-acting injectable testosterone associated with greater risk of erythrocytosis?
Conclusion: Short-acting injectable testosterone is associated with greater risk of erythrocytosis compared with other formulations.
How does testosterone affect EPO and hemoglobin?
Testosterone Administration Stimulates EPO and Shifts the EPO–Hemoglobin Relationship to the Right. ( A) Changes in erythropoietin (EPO) levels during testosterone or placebo administration. EPO levels increased significantly during treatment with testosterone compared with placebo. Mean and 95\% CIs are shown.
How do androgens affect erythropoietin levels?
One of the effects of androgens is to increase the production of erythropoietin. Another is to increase the responsiveness of immature bone marrow cells to the effects of erythropoietin. Simplistically, testosterone increases the output and effectiveness of erythropoietin, which in turn stimulates the production and regulation or red blood cells.